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https://link.springer.com/epdf/10.1186/s12915-022-01354-8?sharing_token=8NH_PmuFIDmUnMqnS7eDHW_BpE1tBhCbnbw3BuzI2RNxPxAmNvJGaf5jnXSloKZ8essdLIRLspnyic_P7M2KT0jCySXztWbKNTLaWFElqjdYdMTOGOwvFkW31ZcQ53yMh9lc8HGL18FTU4NfCx3WkK89R8xB6TNQGDoSakXpdFE%3D